EuroGRAFT
Action number CA17138 COST

Working
Groups

This Action will bring together Chronic GvHD (cGvHD) researchers across Europe for the first time, creating a network of cross-disciplinary experts in the field.

Working Group 5

Immunotherapy

Lead

Prof Marit Inngjerdingen

Country

Norway

Email

mariti@medisin.uio.no

Vice Lead

Ulrike Koehl

Country

Germany

Email

Koehl.Ulrike@mh-hannover.de

Overview

Patients with cGvHD (30-50%) can become refractory to standard therapy, new treatment options and the assessment of current novel therapies are urgently needed to improve the long term outcome and quality of life. In this Working Group the Action will bring together experts in cGVHD and clinical trial development, especially in the realm of cellular therapies with the aim of developing concepts for new approaches including personalized approaches to therapy.

Objective

Investigation of immunotherapeutic challenges for the treatment of cGvHD resistant to conventional therapy.

Task 1

To survey existing and newly developed immunotherapeutic options for the treatment of cGvHD including monoclonal antibodies, ATMPs, and exosomes.

Task 2

One meeting/year will be organized in order to harmonize good manufacturing practice (GMP) protocols for immunotherapy trials for cGvHD in Europe and to assess efficacy/safety criteria in both pre-clinical models and clinical scenarios

Task 3

To define hurdles in immunotherapy trials and to develop an on-line toolbox of documents and Training Schoolsin order to standardise quality control for the use of novel therapies e.g. antibodies ATMP’s and exosomes.

Task 4

To assess and refine pre-clinical animal models for cGvHD to test efficacy of various immunotherapeutic strategies including ATMPs.

Task 5

To survey established and recently defined pathophysiologic mechanisms involved in development of cGvHD that provide a rationale for selection of different immunotherapeutic strategies in individual patients.

Task 6

To survey established and recently developed markers for immune monitoring during and after immunotherapy

 

Milestones

Report – Survey data on various immunotherapy trials for cGvHD treatment Workshop on advanced personalized immunotherapeutic medicine for both the scientific and public community

Report -Survey data on pathophysiological aspects of cGvHD

Report- Survey data on immune monitoring during immunotherapy.

Deliverables

Report -Harmonized guidelines for both GMP manufacturing and quality control of cGvHD therapy e.g. antibodies, ATMPs and exosomes

On-line Training Schools regarding safety issues/side effects of novel immunotherapeutic strategies.

On-line tool box of documentation re quality control for the use of novel therapies

Report-Harmonized guidelines for immune monitoring during immunotherapy Six STSMs across the Working Group

 

Get involved with this Working Group

If you wish to join this Working Group, please email admin.cost17138@ncl.ac.uk or one of the leads.

 

Other working groups

Biomarkers

This Working Group will assess the type and amount of biomarker information which is currently available in the literature and assess those which are worthy of further validation and study.

Socioeconomics/Quality of life

CGvHD is a long term complex disease which has several co-morbidities and as such impacts on the quality of life of patients. By studying the societal impact of the disease via documented quality of life assessments, including reduced working days due to hospital stays, EUROGRAFT will allow an improved assessment of the burden on society of cGvHD at both the individual and European level.

NIH Consensus

The NIH consensus criteria needs to be implemented uniformly if diagnosis and treatment of
cGVHD is to be optimized. The aim of this Working Group will be to aid in both the understanding and
implementation of the NIH Consensus via Training Schools and workshops.

See Also

Find out more about the Action by exploring the site links on the right hand side.

Are you interested
in taking part?

The COST Action EUROGRAFT welcomes research-active scientists working in the field. There are many ways to get involved.

Get involved

Get involved

Do you have a question?

If you have any questions or would like to know more about the project, simply connect with us and we’ll be happy to talk to you.